Friday, May 29, 2015

Monkeying Around at Harvard

Just swinging my way through the Globe jungle:

"Harvard primate lab’s end puzzles researchers; Center leaves legacy of discovery, dispute" by Carolyn Y. Johnson Globe Staff  May 29, 2015

At a secluded research center 25 miles west of Boston, Harvard Medical School scientists have used primates to make key discoveries over the last half-century, earning the center a unique spot in the region’s landscape of prestigious biomedical research institutions.

They unambiguously showed that nicotine is addictive and did experiments that laid the basis for the ongoing quest to develop an HIV vaccine.

You can do your own diagnosis like I have and come to your own conclusions. 

They couldn't have figured the smoking out for themselves?

At the end of May, the long history of the New England Primate Research Center will come to an abrupt end as Harvard takes the unusual step — one that is baffling to many researchers — to close the Southborough facility.

It is one of eight national primate research centers, and in the past half-century, the only one to shut down. Closure is necessary, Harvard says, for “strategic” reasons — not because of a series of high-profile revelations of monkey deaths at the center.

But closure, at a cost to Harvard of $10.8 million so far, has meant the relocation of some 2,000 monkeys, mainly to other centers, layoffs of staff members, loss of faculty, and the end of roughly $25 million a year in research funding. It leaves Harvard in the unusual position of taking a major step back from primate research at a time when the science remains a powerful tool to examine both new and old biomedical threats.

“Primate research is stronger, if you will, more needed, than ever,’’ said John Harding, health scientist administrator for the Division of Comparative Medicine at the National Institutes of Health. “So certainly closing down the Harvard center — which I emphasize was Harvard’s decision not ours — doesn’t in any way speak to the lack of importance of research using non-human primates. Ebola is a very good example of that.”

It's a tough issue, the torture and suffering of sentient beings for our own interests. I $uppo$e live-and-let-live has it's limits. 

By all rights, the center’s epitaph should be its long list of scientific contributions. But mounting evidence threatens to overshadow that legacy, evidence of problems that were deeper and more troubling than Harvard has admitted, with broken lines of communication between the remote center and the leading medical school that owns and operates it.

Those issues were revealed dramatically by the deaths, between 2010 and 2012, of four monkeys, animal care failures that resulted in a $24,000 fine by federal regulators. 

That's the going rate for a monkey's life, huh? $6000 bucks? 

Oddly, it is more than they give Afghans and Pakistanis for wrongful drone strikes. Last I remember it was something like $2500 for a child and $4k for an adult. 

So how much do you think your life is worth? 

Then the Globe reported last month that a dozen monkeys were found dehydrated and dead in their cages or were euthanized for poor health between 1999 and 2011.

Sort of a systemic problem, the neglect.

The deaths reignited complaints from animal rights activists about the center’s treatment of monkeys.

Documents obtained by the Globe show a startling level of disregard for protocols that govern animal research. An internal Harvard investigation of a monkey’s death in 2010, which first attracted public scrutiny to the center, reveals that the incident was only reported after a federal inspector showed up unannounced, 20 days after the death. A scientific journal is looking into a study done at the center because a former director has questioned its integrity, saying that he believes that many of the monkeys included in the research were treated in an inhumane way.

Well, it's done by authority to fellow humans. Called torture (blog editor shrugs shoulders while throwing open palms in the air).

Harvard Medical School dean Dr. Jeffrey Flier said the decision to close the center was unrelated to these problems and the loss will not diminish the university’s research capabilities.

A report prepared by a Harvard committee investigating the initial monkey death in 2010 shows just how high the stakes were in running such a facility. These weren’t minor issues at an out-of-sight suburban campus; the committee saw the problems they uncovered as a direct threat to Harvard’s standing.

“The public at large rightfully expects research with animals to be carried out in the most ethical manner and with the utmost scrutiny as to the animal’s welfare,” the report said.

“Without such scrutiny,’’ the report continued, “we put the institution at risk’’ both reputationally and financially.

Kind of too late for me, all acro$$ the board here in AmeriKa.

In the 1960s, the US government established the regional primate centers, where scientists could study and conduct experiments on animals that are closely related to human beings.

A 1962 Globe article touting the region’s industries and universities included the primate center among its assets: “Harvard Medical School has been given $2.5 million . . . to build a New England primate center to help throw light on man’s diseases.”

The eight centers scattered across the country are an enormous national investment. Harvard has received $268 million in taxpayer-funded base grants since 1980 to maintain its primates, $8 million since 1989 has been given for construction, and many millions more have supported individual research projects.

Time to abort such things. In the name of peace and self-preservation.

Compared with laboratory mice or cells in a dish, primates can provide deep insight into complex behaviors, infectious diseases, or neuropsychological ailments that afflict people. But it is precisely because the animals so closely resemble humans that the research comes with huge responsibilities.

The public trust in the taxpayer-funded enterprise, which is largely closed off to the public due in part to concerns about violence from animal activists, depends on institutions following the Animal Welfare Act and other policies. There are unannounced inspections, but oversight depends largely on the requirement that adverse events be promptly reported so that underlying problems can be quickly corrected.

But those wars being waged by this government across the planet? Getting a big shove from the same pre$$. You see, some violence is a concern, other not so much. Encouraged, even.

At the Southborough primate center, that oversight appears to have been largely delegated to the leadership team in place at the remote, wooded campus. The center is so distant that Flier, the medical school dean, whose name is listed on $90 million worth of taxpayer-funded grants for the center since 2007, said he has been there only three or four times and never visited until after problems began to emerge.

“For many years, the New England Primate Research Center’s leadership team had a track record of advancing science, while Harvard Medical School administrators worked with the center’s on-site management team,” Flier said in a statement.

Ronald Desrosiers, the longtime former director of the center who now works at the University of Miami, did not respond to repeated requests for an interview. But the National Institutes of Health guidelines say the principal investigator on a grant — in this case, Flier — “agrees to accept responsibility for the scientific conduct of the project.”

Flier said that when problems were identified, medical school leadership decisively intervened to make large-scale changes to leadership and procedures.

However, evidence gathered by the Globe suggests that the problems did not happen overnight.

They never do.

Oversight appears to have broken down in fundamental ways and seeped into the culture of the center well before the medical school leadership discovered them.

Cruelty has seeped into all aspects of our culture. Heck, the ma$$ media is promoting celebration of it.

The event that sparked attention to the center occurred on a Wednesday morning in June 2010. According to a report of the Harvard internal investigation obtained by the Globe, two animal technicians waited for a high-temperature wash of a primate cage to finish. When it was done, they made a horrifying discovery: the body of a 7-year-old female monkey on the cage floor. Overcome with emotion, one technician fled the room.

The disturbing event earned Harvard Medical School a slap on the wrist — a warning letter from federal regulators.

But the previously undisclosed internal report found the school’s own investigators were alarmed that nearly three weeks had passed without the animal death being reported to a Harvard committee. The report recommended that new guidelines be drafted, ensuring that this type of death would be reported “within 24 hours or sooner.”

The Harvard report called the delay “a poor decision.”

Official reports of the animal’s death have stated the monkey died prior to going through the wash, but the investigation also found that specialists involved in the necropsy “admit . . . it is nearly impossible to conclude definitively” whether the monkey was dead before the 170 degree wash.

“We implore our senior leaders to support” efforts to fix the relationship with the primate center, the report stated. It noted a problematic disconnect between the animal care technicians and senior management at the center. The report found that staff had “sincere and practical suggestions for improvements.”

The Globe recently also found that Harvard has no evidence that the dozen dehydrated monkey deaths beginning in 1999 were reported to its internal committee that oversees animal care.

Other documents sent by Harvard to federal regulators, obtained through the Freedom of Information Act, suggest that the problems Harvard began identifying in 2011 were wide-ranging.

There was a fundamental breakdown of basic procedures, including “unacceptable and inadequate record-keeping,” an instance in which animals were not euthanized on time, and questions about how federal grants were billed for blood draws. 

Oh, no. There is gold in them gorillas, money in those moneys, cash in those chimps, ugh!

Tuberculosis tests were not administered properly and over a five-year period, six federal certificates required when monkeys are shipped to other facilities were signed by someone without the authority to do so. Harvard’s own letter to regulators mentions the “long-term nature” of the problems.

The apes were spreading tuberculosis?

Harvard has repeatedly said that a committee of external experts was convened to evaluate the center and maintains that problems were self-identified and fixed.


The university has denied requests to see a full copy of the report by the consultants and instead provided a brief summary. A reporter’s request to visit the center as it was closing was also denied.

That explains the lead placement this morning (above-the-fold, upper-right corner is considered the top story; soccer article there is the top feature).

What may be most telling is that after a change in leadership in 2011, a slew of animal care problems was disclosed, when Harvard self-reported three primate deaths in the span of five months. In letters to regulators, Harvard officials praised Dr. Frederick Wang, the interim leader during this period, for the “transformative culture of transparency” he had brought to the center.

In late June 2012, a detailed, 21-page letter to regulators outlined many changes and ended on a strong note.

“Our goal is to ensure that the important science of the [New England Primate Research Center] will continue to further medical breakthroughs, guided by our unwavering commitment to animal welfare,” the unidentified medical school official wrote in the letter.

Ten months later, Flier stunned the research community with the announcement the center would close due to financial reasons.

They control the largest college endowment in the country!

“Is this really where we want to put the school’s resources at a time when we have to make tradeoffs?’’ Flier said in a recent interview. “It just reached a point after 50 years where we said, ‘You know, maybe for the next 50 years, we won’t have a primate center.’ ”

The closure cost includes the expense of shipping the animals to new homes, mostly at other research centers.

Welkin Johnson, a former Harvard faculty member who moved to Boston College from the primate center, said that one of his biggest concerns is for the animals. Extensive precautions and health checks are taken to ensure their welfare before and during transport, but shipping hundreds of monkeys to new homes could cause stress, he said. 

I'm sure it will; not only is the routine changed, the whole social network will need to be reworked when they are introduced to the new population. Could get ugly.

Harvard is currently under an open investigation by federal regulators after six monkeys that arrived healthy at the Oregon Zoo last May died two days later.

Pamela Caudill, chief research operations officer for the medical school, said Harvard is still in discussions with the National Institutes of Health about whether it will have to return any money from the federal construction grants given to the center.

Harvard is also still reviewing its options on what to do with the land. The campus is home to a storage facility for a depository that houses books and other media.

Closing costs are “money that would have been better used to support research that ultimately could have continued to combat diseases like AIDS and Parkinson’s, rather than shutting down a productive research enterprise, mothballing a valuable research campus, and walking away from” millions in federal funding, said R. Paul Johnson, a former director of the primate center who now leads the Yerkes National Primate Research Center at Emory University.

The fact that Harvard, with its considerable resources and its commitment to cutting-edge research, is shutting its center might be seen as a signal that such studies are no longer important or possible, but scientists — including Flier — said the opposite was true. 

That is so often true when reading the pre$$.

“Non-human primate research is alive and well and is definitely financially viable,” said Johnson, of the Yerkes center.


At that center, Johnson said grant awards in the last fiscal year 2014 were up 13 percent over the previous year, to a record $73 million.

Flier said the closure does not create a scientific gap at Harvard and will not erode its leadership in any area. Other scientists disagreed.

“I think that Harvard will grow to regret their loss of preeminence in the primate infectious disease research field, once the dust settles,” wrote Nancy Haigwood, director of the Oregon National Primate Research Center.


Look, I don't want to make anyone angry by pairing this next post, but it did come in the same edition of the same day:

"Deval Patrick urges Harvard graduates to open hearts, minds" by Peter Schworm Globe Staff  May 28, 2015

CAMBRIDGE — Former Massachusetts governor Deval Patrick called on Harvard graduates Thursday to bring a restless idealism to the great challenges of the era — from climate change to the gulf between rich and poor — and to confront racism and inequality with a sense of purpose. 

(Blog editor sighs and just wishes this guy would go away. I will shortly try to explain why in a little more detail)

At the storied university’s commencement ceremony, Patrick urged graduates to avoid complacency and “be a little uneasy” as they embark on careers, leaving themselves open to new ideas and the possibility of confronting even intractable social problems.

Oh, another commencement.

“If enough of us are uneasy, we might begin to feel some urgency,” Patrick said.

Well, he certainly never felt uneasy because under his watch we had (and while he did not create the problems, they got much worse during his tenure): the meningitis murders due to lax regulation; a burgeoning heroin epidemic; marred marijuana clinics; the state unemployment, health, and food stamp websites implode; left the state with a $2 billion whole that was covered up for the campaign and legacy purposes; state drug lab scandals; torture at Bridgewater; a billion borrowed for profitable biotech; and I'm sure were I to sit here a while longer I could come up with some more failures because let's face, even the touted successes (education, environment, MBTA reform) were ultimately failed endeavors.

Oh, right, infrastructure falling apart.... (where did all the goddamn money go?)

His remarks capped a festive day at the university, marked by abiding traditions, nostalgia, and giddy celebration. Graduates posed for pictures with beaming parents, and said farewell to classmates, at least for now. Alumni through the decades reminisced and reunited with old friends.

Did they say a prayer for the monkeys?

On the warm day, graduates sang a centuries-old song in Latin, and men in top hats served as guides. Dressed-up children ran up and down the library steps and told their parents they wanted to go to Harvard, too.

Patrick, who graduated from Harvard in 1978 and was the first in his family to attend college, said the Ivy League school was “not part of my universe” as a child growing up poor on Chicago’s South Side. Harvard graduates are blessed with talent and vast opportunity, he said, but must commit themselves to the possibility of big ideas and sweeping change.

“If you are listening, listening with unease, you will hear the yearnings of a restless world,” he said.

The rustle of corporate and MIT cash to that guy.

In a world that values personal achievement, Patrick urged graduates to embrace a “restlessness that compels you to look beyond yourself for meaning.” He praised recent activist movements, from Occupy Wall Street to Black Lives Matter, for challenging the status quo in the face of “widespread nonchalance about poverty.”

Oh, he really is a piece of work!

“I welcome the engagement of today’s generation of activists,” said Patrick, who also graduated from Harvard Law School, in 1982. By contrast, Harvard students in his day protested the elimination of hot breakfast in a dining hall, he recalled to laughter.

“Will you be uneasy enough to act big?” he asked.

Drew Faust, Harvard’s president, lamented that in a self-absorbed world, the value of public service and collective action are given short shrift.

“This is the era of the selfie, and now the selfie stick,” Faust said. “We direct endless attention to ourselves, our image, our ‘likes.’ ”

This degree of self-absorption carries a cost, Faust said.

“Have we all become so caught up in individual and personal achievements, opportunities, and appearances that we risk forgetting our interdependence, our responsibilities to one another and to the institutions meant to promote the common good,” she asked. “We are larger than ourselves and our selfies,” she added.

UNREAL! Speak for yourself, lady!

The whole elite cla$$ represented by the pre$$ here is $elf-ab$orbed.

Cynthia Torres, president of the Harvard Alumni Association and a 1980 graduate, urged the audience to “experience the full majesty” of commencement. In personal remarks, Torres recalled how her father, a migrant farm worker in California, saw education as a “way out.”

“It was the key to a successful life,” she said.

I'm not saying it was worthless or unimportant; however, it also need to be recognized for the $y$tem of politically-correct indoctrination and inculcation that it has become.

Torres arrived at Harvard unsure of whether she belonged, but found her time there “completely transformative.” 

Yeah, it's Asians they don't like, especially females.

Many students agreed.

“It’s been a beautiful journey,” said Stephen Kim of Fort Lee, N.J., who plans to intern at a record company this summer. “It’s been very rewarding.”

After receiving their degrees in the morning, many students decided to skip the afternoon speeches. It had been a busy few days, they said, and they wanted to savor a little more time with friends.

One group of friends gathered outside a nearby ice cream shop for old time’s sake. They had started going there as freshmen, and never stopped, one said. Then it was on to a bar, where each drink would come with a toast.... 



Okay, enough clowning around.


"Former governor Deval Patrick was honored with a doctorate of law for “helping people to help themselves to the American dream,” the University of Massachusetts Boston Chancellor J. Keith Motley, his voice booming, said. He praised Patrick for overseeing the expansion of affordable health care to Massachusetts residents, and for “funding public education at the highest levels in the history of the Commonwealth.” The crowd erupted into cheers. “You have shared your unshakeable belief in the goodness of our country,” Motley said."

Unfortunately, and this is no endorsement of the guy, 'twas Mitt Romney that did that, and if so why are the schools falling apart?

Also see: Harvard honors Ginsburg for gender-equality advocacy

Oh, Harvard is so hip! 

The self-adulating back-slapping is too much for me this morning, sorry.

UPDATE: Federal agency designates all chimpanzees as endangered

Also see:

With endangered species protection, use of chimpanzees in the lab is limited

Complaint alleging Harvard bias against Asians dismissed