He'll lose.
"Card acknowledged that running as a Republican in Massachusetts is difficult, but he downplayed the notion that Bush’s unpopularity in the state would hamper a potential bid."
Then not only is he a fool, he's an idiot.
See: UMass Protests Andy Card and War
Was Gonzales' Emergency Visit Illegal?
What Did Card Really Whisper to Bush on 9/11
No, we don't want any war-criminal liars as a Senator, I can assure you.
Update: Former White House aide Andrew Card
Also see: Mass. Hypocrisy in Full Flower